BDBM24637 2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole::JMC52379 Compound 5::pyrazole-benzimidazole, 16

SMILES c1cc(n[nH]1)-c1nc2ccccc2[nH]1

InChI Key InChIKey=IYTGPPNUOLLGBE-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 24637   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataIC50:  2.50E+4nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataIC50:  910nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataIC50:  6.50E+3nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Institut de Chimie des Substances Naturelles

Curated by ChEMBL
LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataIC50:  2.80E+4nMAssay Description:CDK2/cyclinA activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataIC50:  910nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataAssay Description:CDK1/cyclinB activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed