BDBM24692 2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl]phenyl}formamido)pentanedioic acid::DDACTHF

SMILES Nc1nc(N)c(CCCCc2ccc(cc2)C(=O)NC(CCC(O)=O)C(O)=O)c(=O)[nH]1

InChI Key InChIKey=LNUHUIPUTGDPDG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 24692   

TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24692(2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5...)
Affinity DataKi:  1.70E+3nM ΔG°:  -7.89kcal/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24692(2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5...)
Affinity DataKi:  1.70E+3nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24692(2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5...)
Affinity DataKi:  2.00E+4nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24692(2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5...)
Affinity DataKi:  2.00E+4nM ΔG°:  -6.43kcal/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed