BDBM24750 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methyl-3,4-dihydropyrimidin-4-one::pyrimidone, 7

SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)c2cc1OC

InChI Key InChIKey=IKPJWGNTDNCFPS-UHFFFAOYSA-N

Data  2 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24750   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24750(2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...)
Affinity DataKi:  39nM ΔG°:  -10.0kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM24750(2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...)
Affinity DataKi: >1.30E+3nM ΔG°: >-7.94kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24750(2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair