BDBM24758 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-6-methyl-3,4-dihydropyrimidin-4-one::pyrimidone, 35

SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3c(C)nc(Cc4ccccc4)[nH]c3=O)c2cc1OC

InChI Key InChIKey=LNXBIINVDNXZNZ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24758   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24758(2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...)
Affinity DataKi:  489nM ΔG°:  -8.52kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24758(2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...)
Affinity DataIC50:  489nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed