BindingDB logo
myBDB logout

BDBM248905 US9434725, 136

SMILES: CCn1cc(cn1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CC[C@@H](N)C1

InChI Key: InChIKey=WXBFQEMPNLLMNB-MRXNPFEDSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 248905   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM248905
PNG
(US9434725, 136)
Show SMILES CCn1cc(cn1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CC[C@@H](N)C1
Show InChI InChI=1S/C20H22N8/c1-2-27-12-15(11-23-27)17-8-18-14(9-22-17)10-24-28(18)20-5-3-4-19(25-20)26-7-6-16(21)13-26/h3-5,8-12,16H,2,6-7,13,21H2,1H3/t16-/m1/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.615 -12.6n/an/an/an/an/a7.225



F. Hoffmann-La Roche Inc

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9434725 (2016)


BindingDB Entry DOI: 10.7270/Q2CF9P1N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248905
PNG
(US9434725, 136)
Show SMILES CCn1cc(cn1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CC[C@@H](N)C1
Show InChI InChI=1S/C20H22N8/c1-2-27-12-15(11-23-27)17-8-18-14(9-22-17)10-24-28(18)20-5-3-4-19(25-20)26-7-6-16(21)13-26/h3-5,8-12,16H,2,6-7,13,21H2,1H3/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.05 -11.8n/an/an/an/an/a7.225



F. Hoffmann-La Roche Inc

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9434725 (2016)


BindingDB Entry DOI: 10.7270/Q2CF9P1N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM248905
PNG
(US9434725, 136)
Show SMILES CCn1cc(cn1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CC[C@@H](N)C1
Show InChI InChI=1S/C20H22N8/c1-2-27-12-15(11-23-27)17-8-18-14(9-22-17)10-24-28(18)20-5-3-4-19(25-20)26-7-6-16(21)13-26/h3-5,8-12,16H,2,6-7,13,21H2,1H3/t16-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
17.3 -10.6n/an/an/an/an/a7.225



F. Hoffmann-La Roche Inc

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9434725 (2016)


BindingDB Entry DOI: 10.7270/Q2CF9P1N
More data for this
Ligand-Target Pair