BDBM249550 US10072016, Compound 148::US10407433, Compound 148::US10913746, Compound 148::US11649240, Compound 148::US9434727, 148::US9777010, Compound 148

SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCc23)C#N)c1Cl

InChI Key InChIKey=DOJQDLFPWKCNSN-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 249550   

TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  5.12nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  7.41nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  7.41nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <0.169nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  5.12nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  7.41nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <1.37nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <0.169nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  5.12nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <1.37nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  5.12nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <1.37nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  5.12nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <1.37nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <1.37nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <0.169nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  5.12nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <1.37nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent