BDBM25144 (2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N-(4-phenyl-1,3-thiazol-2-yl)nonanamide::CHEMBL217651::bis-amide inhibitor, 15

SMILES CN1CCCCC1C(=O)N[C@@H](CCCCCC(C)=O)C(=O)Nc1nc(cs1)-c1ccccc1

InChI Key InChIKey=MVGAXXKEFDOLGL-AIBWNMTMSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 25144   

TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  55nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HDAC8 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of HDAC5 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant C-terminally flag tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HDAC3 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HDAC6 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  170nMAssay Description:Inhibition of HDAC2 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  55nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed