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BDBM256313 US9487488, 37

SMILES: Cc1cc(ccc1C(O)=O)S(=O)(=O)N(Cc1ccc(cn1)C(F)(F)F)c1ncc2ccccc2c1C1CC1

InChI Key: InChIKey=XYMOHDMMDKZSAL-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 256313   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256313
PNG
(US9487488, 37)
Show SMILES Cc1cc(ccc1C(O)=O)S(=O)(=O)N(Cc1ccc(cn1)C(F)(F)F)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C27H22F3N3O4S/c1-16-12-21(10-11-22(16)26(34)35)38(36,37)33(15-20-9-8-19(14-31-20)27(28,29)30)25-24(17-6-7-17)23-5-3-2-4-18(23)13-32-25/h2-5,8-14,17H,6-7,15H2,1H3,(H,34,35)
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PC cid
PC sid
UniChem
US Patent
n/an/a 9.5n/an/an/an/an/a37



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)


BindingDB Entry DOI: 10.7270/Q2MG7NGT
More data for this
Ligand-Target Pair