BDBM25733 CHEMBL476614::Urea-based compound, 14::methyl 4-[(adamantan-1-ylcarbamoyl)amino]-2-hydroxybenzoate

SMILES COC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1O

InChI Key InChIKey=PXJSHQUWAKRZPH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25733   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25733(CHEMBL476614 | Urea-based compound, 14 | methyl 4-...)
Affinity DataIC50:  30nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM25733(CHEMBL476614 | Urea-based compound, 14 | methyl 4-...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM25733(CHEMBL476614 | Urea-based compound, 14 | methyl 4-...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM25733(CHEMBL476614 | Urea-based compound, 14 | methyl 4-...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed