BDBM257675 US9493446, 145

SMILES Cc1ccc(c(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c1F)-n1nccn1

InChI Key InChIKey=AEVKXGFMSDEVKH-INIZCTEOSA-N

Data  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 257675   

TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

US Patent
LigandPNGBDBM257675(US9493446, 145)
Show SMILES Cc1ccc(c(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c1F)-n1nccn1
Show InChI InChI=1S/C23H18F4N6O3/c1-13-8-9-15(33-28-10-11-29-33)18(19(13)24)22(34)32-12-4-6-16(32)21-30-20(31-36-21)14-5-2-3-7-17(14)35-23(25,26)27/h2-3,5,7-11,16H,4,6,12H2,1H3/t16-/m0/s1
Affinity DataIC50: 15nMT: 2°CAssay Description:Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

US Patent
LigandPNGBDBM257675(US9493446, 145)
Show SMILES Cc1ccc(c(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c1F)-n1nccn1
Show InChI InChI=1S/C23H18F4N6O3/c1-13-8-9-15(33-28-10-11-29-33)18(19(13)24)22(34)32-12-4-6-16(32)21-30-20(31-36-21)14-5-2-3-7-17(14)35-23(25,26)27/h2-3,5,7-11,16H,4,6,12H2,1H3/t16-/m0/s1
Affinity DataIC50: 19nMT: 2°CAssay Description:Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid