BindingDB logo
myBDB logout

BDBM259935 US9512121, 12

SMILES: Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncc(-c5cnn(C)c5)c(OCC5CC5)c4c3)n2c1

InChI Key: InChIKey=MUWNWVAEJNEOIB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 259935   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM259935
PNG
(US9512121, 12)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncc(-c5cnn(C)c5)c(OCC5CC5)c4c3)n2c1
Show InChI InChI=1S/C27H24N8OS/c1-33-13-19(10-29-33)18-5-8-25-31-32-27(35(25)15-18)37-21-6-7-24-22(9-21)26(36-16-17-3-4-17)23(12-28-24)20-11-30-34(2)14-20/h5-15,17H,3-4,16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 28.3n/an/an/an/an/a20



Jiangsu Hansoh Pharmaceutical Co., Ltd.

US Patent


Assay Description
Experimental Purpose: The purpose is to study the effect of the compounds on c-MET tyrosine kinase activity at the molecular level. IC50 values were ...


US Patent US9512121 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NSV
More data for this
Ligand-Target Pair