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BDBM260343 US9522914, D-32

SMILES: CC(C)(C)NC(=O)Cc1nn(-c2ccc(CCN3CCOCC3)cn2)c(=O)n1-c1ccc(F)c(Cl)c1

InChI Key: InChIKey=AYDHJTKSXURNLQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 260343   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM260343
PNG
(US9522914, D-32)
Show SMILES CC(C)(C)NC(=O)Cc1nn(-c2ccc(CCN3CCOCC3)cn2)c(=O)n1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C25H30ClFN6O3/c1-25(2,3)29-23(34)15-22-30-33(24(35)32(22)18-5-6-20(27)19(26)14-18)21-7-4-17(16-28-21)8-9-31-10-12-36-13-11-31/h4-7,14,16H,8-13,15H2,1-3H3,(H,29,34)
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/a7.425



Taisho Pharmaceutical Co., Ltd

US Patent


Assay Description
Human V1b receptor was transiently expressed in 293FT cells (Invitrogen). The cells were collected and then homogenated in a 15 mmol/L tris-hydrochlo...


US Patent US9522914 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6PR7
More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM260343
PNG
(US9522914, D-32)
Show SMILES CC(C)(C)NC(=O)Cc1nn(-c2ccc(CCN3CCOCC3)cn2)c(=O)n1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C25H30ClFN6O3/c1-25(2,3)29-23(34)15-22-30-33(24(35)32(22)18-5-6-20(27)19(26)14-18)21-7-4-17(16-28-21)8-9-31-10-12-36-13-11-31/h4-7,14,16H,8-13,15H2,1-3H3,(H,29,34)
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/a7.44



Taisho Pharmaceutical Co., Ltd

US Patent


Assay Description
Human V1b receptor was transiently expressed in 293FT cells (Invitrogen). The cells were collected and then homogenated in a 15 mmol/L tris-hydrochlo...


US Patent US9522914 (2016)


BindingDB Entry DOI: 10.7270/Q2WM1CB9
More data for this
Ligand-Target Pair