BDBM26114 CHEMBL88972::pyridine carboxylate, 6b::pyridine-2,5-dicarboxylic acid

SMILES OC(=O)c1ccc(nc1)C(O)=O

InChI Key InChIKey=LVPMIMZXDYBCDF-UHFFFAOYSA-N

Data  3 KI  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 26114   

TargetProlyl 4-hydroxylase subunit alpha-1(Rattus norvegicus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataKi:  800nMAssay Description:Inhibitory activity against prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataKi:  2.60E+3nMpH: 7.8Assay Description:Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Aeromonas hydrophila)
Universit£

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataKi:  4.20E+5nMAssay Description:Inhibition of Aeromonas hydrophila beta lactamase CphA by competitive inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Rattus norvegicus)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  5.18E+3nMAssay Description:Compound was evaluated for the inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  5.18E+3nMAssay Description:Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumnaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of prolyl 4-hydroxylase activity by an indirect assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  1.80E+5nMpH: 7.5 T: 2°CAssay Description:A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  1.50E+4nMpH: 7.8Assay Description:Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed