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BDBM261924 2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-1,2,3,4-tetrahydropyrido[4,3-d]pyrimidin-7-yl)pyridin-2-yl)-2-methylpropanenitrile::US10251892, Example 26::US10632126, Example 26::US9708318, 26

SMILES: CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F

InChI Key: InChIKey=CLJRYESQRHIHOJ-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 261924   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261924
PNG
(2-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(C)(C)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-6-32-18-9-17(15-7-8-21(31-11-15)26(2,3)14-29)30-12-16(18)13-33(25(32)34)24-22(27)19(35-4)10-20(36-5)23(24)28/h7-12H,6,13H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair