BDBM26194 4-Hydroxybenzoate, III::4-hydroxybenzoic acid::CHEMBL441343::p-Hydroxybenzoic acid::phenol derivative, 8

SMILES OC(=O)c1ccc(O)cc1

InChI Key InChIKey=FJKROLUGYXJWQN-UHFFFAOYSA-N

Data  31 KI  7 IC50  1 EC50

PDB links: 63 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 26194   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  870nMAssay Description:Inhibition of human CA2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  920nMAssay Description:Inhibition of human CA1 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  3.67E+3nMAssay Description:Inhibition of human CA5A by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  3.73E+3nMAssay Description:Inhibition of human CA9 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  4.08E+3nMAssay Description:Inhibition of human CA7 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  4.80E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  5.70E+3nMAssay Description:Inhibition of human CA6 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  6.16E+3nMAssay Description:Inhibition of human CA14 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  6.27E+3nMAssay Description:Inhibition of human CA12 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  6.61E+3nMAssay Description:Inhibition of human CA3 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  7.13E+3nMAssay Description:Inhibition of human CA5B by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  7.78E+3nMAssay Description:Inhibition of human CA4 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Mus musculus (mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  7.79E+3nMAssay Description:Inhibition of mouse CA13 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Dicentrarchus labrax)
Gumushane University

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  8.46E+3nMAssay Description:Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  9.20E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 15(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  9.32E+3nMAssay Description:Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  9.80E+3nM ΔG°:  -6.83kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  1.05E+4nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  1.06E+4nM ΔG°:  -6.78kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  1.14E+4nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  3.43E+4nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Mus musculus (mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  8.60E+4nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  1.18E+5nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  6.75E+5nM ΔG°:  -4.32kcal/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion using s...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  6.96E+5nM ΔG°:  -4.30kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  7.16E+5nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  8.09E+5nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  1.06E+6nM ΔG°:  -4.05kcal/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion using s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Gallus gallus (Chicken))
University Of Oulu

LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataKi:  3.20E+6nMAssay Description:Inhibition assay using procollagen-prolin, 2-oxoglutarate 4-dioxygenase.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSuccinate-semialdehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Huazhong University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against SSADHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kinki University

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate preincubated for 10 mins followed by enzyme addition measured after 20 mins by microp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Hiroshima University

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataIC50:  9.35E+3nMAssay Description:Compound was evaluated for binding affinity against Dihydrofolate reductase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 2(Mus musculus)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataIC50:  1.18E+5nMAssay Description:Antagonist activity at TLR2 in mouse RAW264.7 cells assessed as PAM3CSK4-induced NO production measured after 24 hrs by Griess assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Kinki University

LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataIC50: >3.00E+5nMpH: 7.0 T: 2°CAssay Description:α-glucosidase (25 μL, 0.2 U/mL), 25 μL of various concentrations of samples, and 175 μL of 50 mM sodium phosphate buffer (pH 7.0)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-aminobutyrate aminotransferase, mitochondrial(Homo sapiens (Human))
Huazhong University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against GABATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataIC50:  7.24E+4nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM26194(4-Hydroxybenzoate, III | 4-hydroxybenzoic acid | C...)
Affinity DataEC50:  1.10nMAssay Description:Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed