BindingDB logo
myBDB logout

BDBM262061 5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-1,2,3,4-tetrahydropyrido[4,3-d]pyrimidin-7-yl)-N-propylpicolinamide::US10251892, Example 179::US10632126, Example 179::US9708318, 179

SMILES: CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F

InChI Key: InChIKey=ZNTXFVRMSWLFHJ-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 262061   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262061
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCCNC(=O)c1ccc(cn1)-c1cc2N(CC)C(=O)N(Cc2cn1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-5-9-29-25(34)17-8-7-15(12-30-17)18-10-19-16(13-31-18)14-33(26(35)32(19)6-2)24-22(27)20(36-3)11-21(37-4)23(24)28/h7-8,10-13H,5-6,9,14H2,1-4H3,(H,29,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair