BindingDB logo
myBDB logout

BDBM262076 3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dimethyl-1H-pyrazol-4-yl)-1- ((2-methylpyrimidin-4- yl)methyl)-3,4- dihydropyrido[4,3-d]pyrimidin- 2(1H)-one::US10251892, Example 121::US9708318, 121

SMILES: COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F

InChI Key: InChIKey=KDHHOAIJSIAOHA-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 262076   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 115n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)


BindingDB Entry DOI: 10.7270/Q2MC9298
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262076
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F2N7O3/c1-14-18(13-33(3)32-14)19-8-20-16(10-30-19)11-35(25-23(27)21(37-4)9-22(38-5)24(25)28)26(36)34(20)12-17-6-7-29-15(2)31-17/h6-10,13H,11-12H2,1-5H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 115n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...


US Patent US9708318 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3HD3
More data for this
Ligand-Target Pair