BDBM26267 RO-154513::Ro15-4513::[3H]Ro15-4513::ethyl 12-azido-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,11,13-pentaene-5-carboxylate

SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-]

InChI Key InChIKey=CFSOJZTUTOQNIA-UHFFFAOYSA-N

Data  35 KI  1 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 26267   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  0.270nMAssay Description:Binding affinity for Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  0.300nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.5nMAssay Description:Binding affinity against alpha3-beta3-gamma2 GABAA/BzR receptor subtype.More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.5nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.5nMAssay Description:Binding affinity for human GABA-A receptor alpha-3-beta-2-gamma-2 expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.60nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.60nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.60nMAssay Description:Binding affinity for human GABA-A receptor alpha-2-beta-2-gamma-2 expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.60nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.60nMAssay Description:Binding affinity of the compound tested against alpha2-beta3-gamma2 GABAA/BzR receptor subtype.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-4(Homo sapiens (Human))
Cocensys

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  2.62nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-4 [36-554]/beta-2 [26-512]/gamma-2 [40-467](Homo sapiens (Human))
University Of Wisconsin At Madison

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.10nM ΔG°:  -11.5kcal/molepH: 7.4 T: 2°CAssay Description:Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.30nMAssay Description:Binding affinity for human GABA-A receptor alpha-1-beta-2-gamma-2 expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.30nMAssay Description:Binding affinity against alpha1-beta3-gamma2 GABAA/BzR receptor subtype.More data for this Ligand-Target Pair

Target InfoGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.30nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair

Target InfoGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-4(Rattus norvegicus (Rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.80nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.80nMAssay Description:Binding affinity for human GABA-A receptor alpha-6-beta-2-gamma-2 expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.80nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  3.80nMAssay Description:Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6 [20-453]/beta-2 [26-512]/gamma-2 [40-467](Homo sapiens (Human))
University Of Wisconsin At Madison

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  5.10nM ΔG°:  -11.2kcal/molepH: 7.4 T: 2°CAssay Description:Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6(RAT)
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  5.30nMMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]Ro-154513 from GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in Sf9 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]-Ro- 15-4513 from alpha-6-beta-2-gamma-2 GABA-A receptor subunits expressed in Sf9 cell membranesMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-4(Homo sapiens (Human))
Cocensys

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  5.5nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-3(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  7.80nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  8.10nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  10nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  10.4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-4(Homo sapiens (Human))
Cocensys

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  10.5nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-6(Homo sapiens (Human))
Cocensys

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  11.7nMMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  15nMAssay Description:Displacement of [3H]Flunitrazepam from GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in Sf9 cellsMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataKi:  33nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair

Target InfoGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

LigandBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Copy SMILESCopy InChI

Affinity DataEC50:  1.10nMAssay Description:Activity at rat wild type GABAA alpha1beta2gamma2 receptor expressed in xenopus oocytes assessed as GABA-elicited response by two electrode voltage c...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI