BDBM26305 4-aminopyrazole quinazoline, 5::N-(3-fluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

SMILES COc1cc2c(Nc3cnn(CC(=O)Nc4cccc(F)c4)c3)ncnc2cc1OCCCN1CCC[C@@H]1CO

InChI Key InChIKey=ACDXDLIQFJBPHN-JOCHJYFZSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26305   

TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26305(4-aminopyrazole quinazoline, 5 | N-(3-fluorophenyl...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26305(4-aminopyrazole quinazoline, 5 | N-(3-fluorophenyl...)
Affinity DataKi:  1.30E+3nM ΔG°:  -7.94kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed