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BDBM264120 3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phenyl)piperazin-1-yl)butyl)-1H-indole-5-carbonitrile::US9714232, 33

SMILES: O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1

InChI Key: InChIKey=RLGFCRXXEKJBKA-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264120   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM264120
PNG
(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H29N5O2/c31-20-22-4-9-28-27(19-22)23(21-32-28)3-1-2-12-33-14-16-34(17-15-33)24-5-7-25(8-6-24)35-13-10-29-26(30(35)36)11-18-37-29/h4-11,13,18-19,21,32H,1-3,12,14-17H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
0.140n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM264120
PNG
(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H29N5O2/c31-20-22-4-9-28-27(19-22)23(21-32-28)3-1-2-12-33-14-16-34(17-15-33)24-5-7-25(8-6-24)35-13-10-29-26(30(35)36)11-18-37-29/h4-11,13,18-19,21,32H,1-3,12,14-17H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 0.530n/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37 C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair