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BDBM26838 N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoylethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-ylidene]-5-(pyridin-2-yl)thiophene-2-carboxamide::acylated 2-aminobenzimidazole, 32

SMILES: CN(C(=O)c1ccccc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(s3)-c3ccccn3)nc2c1

InChI Key: InChIKey=JEGQJSKRWOBVEP-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26838   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens (Human))
BDBM26838
PNG
(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Show SMILES CN(C(=O)c1ccccc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(s3)-c3ccccn3)nc2c1
Show InChI InChI=1S/C28H24N6O3S/c1-33(27(37)18-7-3-2-4-8-18)19-10-11-22-21(17-19)31-28(34(22)16-14-25(29)35)32-26(36)24-13-12-23(38-24)20-9-5-6-15-30-20/h2-13,15,17H,14,16H2,1H3,(H2,29,35)(H,31,32,36)
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Article
PubMed
n/an/a>6.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...


Bioorg Med Chem Lett 19: 773-7 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.028
BindingDB Entry DOI: 10.7270/Q2736P62
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM26838
PNG
(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Show SMILES CN(C(=O)c1ccccc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(s3)-c3ccccn3)nc2c1
Show InChI InChI=1S/C28H24N6O3S/c1-33(27(37)18-7-3-2-4-8-18)19-10-11-22-21(17-19)31-28(34(22)16-14-25(29)35)32-26(36)24-13-12-23(38-24)20-9-5-6-15-30-20/h2-13,15,17H,14,16H2,1H3,(H2,29,35)(H,31,32,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 19n/an/an/an/a7.022



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...


Bioorg Med Chem Lett 19: 773-7 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.028
BindingDB Entry DOI: 10.7270/Q2736P62
More data for this
Ligand-Target Pair