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BDBM269685 2-(2-cyano-4-fluorophenyl)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)ethanesulfonamide::US10058550, Example 200.0

SMILES: COc1cccc(n1)-c1nnc(NS(=O)(=O)CCc2ccc(F)cc2[N+]#[C-])n1-c1c(OC)cccc1OC

InChI Key: InChIKey=IYUBSDJVTKNZLS-UHFFFAOYSA-N

Data: 1 EC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 269685   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens (Human))
BDBM269685
PNG
(2-(2-cyano-4-fluorophenyl)-N-(4-(2,6-dimethoxyphen...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)CCc2ccc(F)cc2[N+]#[C-])n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H23FN6O5S/c1-27-19-15-17(26)12-11-16(19)13-14-38(33,34)31-25-30-29-24(18-7-5-10-22(28-18)37-4)32(25)23-20(35-2)8-6-9-21(23)36-3/h5-12,15H,13-14H2,2-4H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.570n/an/a7.5n/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair