BDBM270576 (S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl)-N4- neopentylquinazoline- 4,6-diamine::US10059695, I-8::US10577352, Compound I-8

SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccccc3Cl)cc12

InChI Key InChIKey=KKQZQORNQXJZDZ-QHCPKHFHSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270576   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270576((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...)
Affinity DataIC50:  13nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270576((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...)
Affinity DataEC50:  169nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270576((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...)
Affinity DataIC50:  13nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270576((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...)
Affinity DataEC50:  169nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent