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BDBM2715 3-[(2R)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::Bisindolylmaleimide deriv. 23b

SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@H](CN)CCn3c3ccccc23)c2ccccc12

InChI Key: InChIKey=QQKKPWJFHBFCTH-OAHLLOKOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2715   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2715
PNG
(3-[(2R)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@H](CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)/t15-/m1/s1
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 900n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2715
PNG
(3-[(2R)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@H](CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)/t15-/m1/s1
PDB

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UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair