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BDBM274623 2-(tert-butyl)-N-(6-(2-(4- fluorophenyl)imidazo[1,2-a] pyridin-3-yl)imidazo[1,2-b] pyridazin-2-yl)isonicotinamide::US9556179, Compound 197

SMILES: CC(C)(C)c1cc(ccn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1

InChI Key: InChIKey=BIXMZJKSDYSJET-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274623   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274623
PNG
(2-(tert-butyl)-N-(6-(2-(4- fluorophenyl)imidazo[1,...)
Show SMILES CC(C)(C)c1cc(ccn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H24FN7O/c1-29(2,3)22-16-19(13-14-31-22)28(38)33-23-17-37-25(32-23)12-11-21(35-37)27-26(18-7-9-20(30)10-8-18)34-24-6-4-5-15-36(24)27/h4-17H,1-3H3,(H,33,38)
PDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.99n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274623
PNG
(2-(tert-butyl)-N-(6-(2-(4- fluorophenyl)imidazo[1,...)
Show SMILES CC(C)(C)c1cc(ccn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H24FN7O/c1-29(2,3)22-16-19(13-14-31-22)28(38)33-23-17-37-25(32-23)12-11-21(35-37)27-26(18-7-9-20(30)10-8-18)34-24-6-4-5-15-36(24)27/h4-17H,1-3H3,(H,33,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.98n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair