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BDBM274628 6-(tert-butyl)-N-(6-(2-(4- fluorophenyl)imidazo[1,2-a] pyridin-3-yl)imidazo[1,2-b] pyridazin-2-yl)pyrimidine- 4-carboxamide::US9556179, Compound 202

SMILES: CC(C)(C)c1cc(ncn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1

InChI Key: InChIKey=MGLSMNVAIOHXTD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274628   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274628
PNG
(6-(tert-butyl)-N-(6-(2-(4- fluorophenyl)imidazo[1,...)
Show SMILES CC(C)(C)c1cc(ncn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN8O/c1-28(2,3)21-14-20(30-16-31-21)27(38)33-22-15-37-24(32-22)12-11-19(35-37)26-25(17-7-9-18(29)10-8-17)34-23-6-4-5-13-36(23)26/h4-16H,1-3H3,(H,33,38)
PDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.84n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274628
PNG
(6-(tert-butyl)-N-(6-(2-(4- fluorophenyl)imidazo[1,...)
Show SMILES CC(C)(C)c1cc(ncn1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc2ccccn12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN8O/c1-28(2,3)21-14-20(30-16-31-21)27(38)33-22-15-37-24(32-22)12-11-19(35-37)26-25(17-7-9-18(29)10-8-17)34-23-6-4-5-13-36(23)26/h4-16H,1-3H3,(H,33,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 28.1n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair