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BDBM274682 N-(6-(1-cyclohexyl-4-(4-fluoro- phenyl)-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide::US9556179, Compound 257

SMILES: Fc1ccc(cc1)-c1ncn(C2CCCCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1

InChI Key: InChIKey=DDLCSSGGXQDPLM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274682   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274682
PNG
(N-(6-(1-cyclohexyl-4-(4-fluoro- phenyl)-1H-imidazo...)
Show SMILES Fc1ccc(cc1)-c1ncn(C2CCCCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1
Show InChI InChI=1S/C27H23F2N7O/c28-19-8-6-17(7-9-19)25-26(35(16-31-25)20-4-2-1-3-5-20)21-10-11-24-32-23(15-36(24)34-21)33-27(37)18-12-13-30-22(29)14-18/h6-16,20H,1-5H2,(H,33,37)
PDB

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UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.325n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274682
PNG
(N-(6-(1-cyclohexyl-4-(4-fluoro- phenyl)-1H-imidazo...)
Show SMILES Fc1ccc(cc1)-c1ncn(C2CCCCC2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1
Show InChI InChI=1S/C27H23F2N7O/c28-19-8-6-17(7-9-19)25-26(35(16-31-25)20-4-2-1-3-5-20)21-10-11-24-32-23(15-36(24)34-21)33-27(37)18-12-13-30-22(29)14-18/h6-16,20H,1-5H2,(H,33,37)
PDB

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KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.29n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair