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BDBM274683 N-(6-(1-(2,2-dimethylpropyl)-4-(4- fluorophenyl)-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide::US9556179, Compound 258

SMILES: CC(C)(C)Cn1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1

InChI Key: InChIKey=AZMHYBXPYDTVER-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274683   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274683
PNG
(N-(6-(1-(2,2-dimethylpropyl)-4-(4- fluorophenyl)-1...)
Show SMILES CC(C)(C)Cn1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H23F2N7O/c1-26(2,3)14-34-15-30-23(16-4-6-18(27)7-5-16)24(34)19-8-9-22-31-21(13-35(22)33-19)32-25(36)17-10-11-29-20(28)12-17/h4-13,15H,14H2,1-3H3,(H,32,36)
PDB

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UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.393n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274683
PNG
(N-(6-(1-(2,2-dimethylpropyl)-4-(4- fluorophenyl)-1...)
Show SMILES CC(C)(C)Cn1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H23F2N7O/c1-26(2,3)14-34-15-30-23(16-4-6-18(27)7-5-16)24(34)19-8-9-22-31-21(13-35(22)33-19)32-25(36)17-10-11-29-20(28)12-17/h4-13,15H,14H2,1-3H3,(H,32,36)
PDB

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KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.56n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair