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BDBM274719 N-(6-(4-(4-chlorophenyl)-1-(2,2- difluoroethyl)-2-methyl-1H- imidazol-5-yl)imidazo[1,2-b] pyridazin-2-yl)-2-fluoroiso- nicotinamide::US9556179, Compound 294

SMILES: Cc1nc(c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)n1CC(F)F)-c1ccc(Cl)cc1

InChI Key: InChIKey=YGLUPSVROQFDCO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274719   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274719
PNG
(N-(6-(4-(4-chlorophenyl)-1-(2,2- difluoroethyl)-2-...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)n1CC(F)F)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H17ClF3N7O/c1-13-30-22(14-2-4-16(25)5-3-14)23(34(13)11-18(26)27)17-6-7-21-31-20(12-35(21)33-17)32-24(36)15-8-9-29-19(28)10-15/h2-10,12,18H,11H2,1H3,(H,32,36)
PDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.208n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274719
PNG
(N-(6-(4-(4-chlorophenyl)-1-(2,2- difluoroethyl)-2-...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)n1CC(F)F)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H17ClF3N7O/c1-13-30-22(14-2-4-16(25)5-3-14)23(34(13)11-18(26)27)17-6-7-21-31-20(12-35(21)33-17)32-24(36)15-8-9-29-19(28)10-15/h2-10,12,18H,11H2,1H3,(H,32,36)
PDB

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KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.03n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair