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BDBM274748 N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2- yl)-2-morpholinoisonicotin- amide::US9556179, Compound 324

SMILES: Cc1nc(c(-c2ccc3nc(NC(=O)c4ccnc(c4)N4CCOCC4)cn3n2)n1C)-c1ccc(F)cc1

InChI Key: InChIKey=LTGPUJTXPPHNNC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274748   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274748
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccnc(c4)N4CCOCC4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25FN8O2/c1-17-30-25(18-3-5-20(28)6-4-18)26(34(17)2)21-7-8-23-31-22(16-36(23)33-21)32-27(37)19-9-10-29-24(15-19)35-11-13-38-14-12-35/h3-10,15-16H,11-14H2,1-2H3,(H,32,37)
PDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.344n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274748
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccnc(c4)N4CCOCC4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25FN8O2/c1-17-30-25(18-3-5-20(28)6-4-18)26(34(17)2)21-7-8-23-31-22(16-36(23)33-21)32-27(37)19-9-10-29-24(15-19)35-11-13-38-14-12-35/h3-10,15-16H,11-14H2,1-2H3,(H,32,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.91n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair