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BDBM274846 2,6-Difluoro-N-(6-(4- (4-fluorophenyl)-1- (pyridin-3-yl)-1H- imidazol-5-yl)imidazo[1,2- b]pyridazin-2-yl)isonicotinamide::US9556179, Compound 423

SMILES: Fc1ccc(cc1)-c1ncn(c1-c1ccc2nc(NC(=O)c3cc(F)nc(F)c3)cn2n1)-c1cccnc1

InChI Key: InChIKey=GGALBQCGKDMXRN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274846   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274846
PNG
(2,6-Difluoro-N-(6-(4- (4-fluorophenyl)-1- (pyridin...)
Show SMILES Fc1ccc(cc1)-c1ncn(c1-c1ccc2nc(NC(=O)c3cc(F)nc(F)c3)cn2n1)-c1cccnc1
Show InChI InChI=1S/C26H15F3N8O/c27-17-5-3-15(4-6-17)24-25(36(14-31-24)18-2-1-9-30-12-18)19-7-8-23-33-22(13-37(23)35-19)34-26(38)16-10-20(28)32-21(29)11-16/h1-14H,(H,34,38)
PDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274846
PNG
(2,6-Difluoro-N-(6-(4- (4-fluorophenyl)-1- (pyridin...)
Show SMILES Fc1ccc(cc1)-c1ncn(c1-c1ccc2nc(NC(=O)c3cc(F)nc(F)c3)cn2n1)-c1cccnc1
Show InChI InChI=1S/C26H15F3N8O/c27-17-5-3-15(4-6-17)24-25(36(14-31-24)18-2-1-9-30-12-18)19-7-8-23-33-22(13-37(23)35-19)34-26(38)16-10-20(28)32-21(29)11-16/h1-14H,(H,34,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/a7.425



Bristol-Myers Squibb Co.

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)


BindingDB Entry DOI: 10.7270/Q2G73GR5
More data for this
Ligand-Target Pair