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BDBM27571 5-[(3-methyl-1H-indazol-4-yl)oxy]benzene-1,3-dicarbonitrile::Indazole Derivative, 1

SMILES: Cc1n[nH]c2cccc(Oc3cc(cc(c3)C#N)C#N)c12

InChI Key: InChIKey=BXHPUNFRXKKZLS-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27571   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM27571
PNG
(5-[(3-methyl-1H-indazol-4-yl)oxy]benzene-1,3-dicar...)
Show SMILES Cc1n[nH]c2cccc(Oc3cc(cc(c3)C#N)C#N)c12
Show InChI InChI=1S/C16H10N4O/c1-10-16-14(20-19-10)3-2-4-15(16)21-13-6-11(8-17)5-12(7-13)9-18/h2-7H,1H3,(H,19,20)
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 332n/an/an/an/a7.837



Pfizer Inc



Assay Description
The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...


J Med Chem 52: 1219-23 (2009)


Article DOI: 10.1021/jm801322h
BindingDB Entry DOI: 10.7270/Q2707ZRW
More data for this
Ligand-Target Pair
3D
3D Structure (docked)