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BDBM275796 5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)oxy)-N-(N,N- dibutylsulfamoyl)- 2-fluorobenzamide::US10071957, Example 13

SMILES: CCCCN(CCCC)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F

InChI Key: InChIKey=QEDSPJWLPLEROB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275796   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275796
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CCCCN(CCCC)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C24H32Cl2FN3O5S/c1-5-7-9-30(10-8-6-2)36(32,33)29-23(31)18-12-19(25)22(13-21(18)27)35-17-11-20(26)24(28-14-17)34-15-16(3)4/h11-14,16H,5-10,15H2,1-4H3,(H,29,31)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.64E+3n/an/an/an/a7.425



Genentech Inc

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)


BindingDB Entry DOI: 10.7270/Q2J1056P
More data for this
Ligand-Target Pair