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BDBM275850 5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- propoxy)pyridin-3- yl)oxy)-2-fluoro-N- (pyridin-3-ylsulfonyl) benzamide::US10071957, Example 69

SMILES: FC(F)C(F)(F)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cccnc2)cc1Cl

InChI Key: InChIKey=PDEUXVUBGVHODQ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275850   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275850
PNG
(5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- pro...)
Show SMILES FC(F)C(F)(F)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cccnc2)cc1Cl
Show InChI InChI=1S/C20H12Cl2F5N3O5S/c21-13-5-12(17(31)30-36(32,33)11-2-1-3-28-8-11)15(23)6-16(13)35-10-4-14(22)18(29-7-10)34-9-20(26,27)19(24)25/h1-8,19H,9H2,(H,30,31)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 950n/an/an/an/a7.425



Genentech Inc

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)


BindingDB Entry DOI: 10.7270/Q2J1056P
More data for this
Ligand-Target Pair