BDBM27889 8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-5-oxo-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxamide::Pyrido[2,3-d]pyrimidin-5-one, 10

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1

InChI Key InChIKey=SHCFJIXSPWRTLY-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 27889   

TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  13nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  56nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TrkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50: >300nMAssay Description:Inhibition of AxlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed