BDBM278991 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 21::US10512632, Example 21::US10766893, Example S21::US10806718, Example 21::US11026923, Example 21::US11491140, Example 21::US11634416, Example 21

SMILES CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C

InChI Key InChIKey=GPZPPQFWVLHHBU-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 278991   

LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  8.90nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  29nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  8.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  0.440nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  8.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  0.440nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  8.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  0.440nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  8.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  0.440nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  8.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  0.440nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  8.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  0.440nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278991(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  0.440nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent