BDBM279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39::US10512632, Example 39::US10766893, Example S39::US10806718, Example 39::US11026923, Example 39::US11491140, Example 39::US11634416, Example 39

SMILES CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=UOWVOVPKNPTQQH-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 279009   

LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  8.10nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  13nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  8.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  0.430nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  8.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  0.430nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  8.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  0.430nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  8.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  0.430nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  8.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  0.430nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  8.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  0.430nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279009(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Affinity DataIC50:  0.430nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent