BDBM279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70

SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC

InChI Key InChIKey=PNGBBNJWUZFNIY-UHFFFAOYSA-N

Data  33 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 279039   

LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  40nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  140nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  360nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  1.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  40nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  1.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  40nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  1.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  40nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  1.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  40nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  1.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  40nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279039(5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-me...)
Affinity DataIC50:  1.20nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent