BDBM279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86

SMILES CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=LOZUTDKVJLMDTB-UHFFFAOYSA-N

Data  75 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 75 hits for monomerid = 279055   

LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  20nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  0.360nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  68nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  40nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  5.5nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  46nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  27nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  0.770nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  78nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  31nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  1.60nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  84nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  24nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  1.10nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  61nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  27nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  0.770nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  78nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  31nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  1.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  84nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  24nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  1.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  61nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  0.360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  68nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  0.360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  68nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  31nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  1.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  84nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  24nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  1.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  61nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  0.360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  68nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  27nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  0.770nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  78nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  31nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  1.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  84nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  24nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  1.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  61nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
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LigandPNGBDBM279055(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3...)
Affinity DataIC50:  0.360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
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