BDBM279112 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 143::US10512632, Example 143::US10766893, Example S143::US10806718, Example 143::US11026923, Example 143::US11491140, Example 143::US11634416, Example 143

SMILES CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=WVFCCHYAETYKIF-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 279112   

LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  3.80nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  9.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  9.20nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  3.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  9.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  3.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  9.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  3.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  9.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  3.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  9.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  3.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  9.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  3.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279112(1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H...)
Affinity DataIC50:  0.260nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent