BDBM280343 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-pyridyl]amino]-N-(2-hydroxy-1,1-dimethyl-ethyl)pyridine-3-carboxamide::US10030004, Compound 8::US10501436, Compound 8::US11053216, Compound 8::US11702401, Compound 8

SMILES CC(=C)c1cnc(cc1Nc1ccncc1C(=O)NC(C)(C)CO)-c1cc(Cl)ccc1F

InChI Key InChIKey=DSJFEZATROEIML-UHFFFAOYSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 280343   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  99.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  502nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  99.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  502nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  99.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  502nMMore data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  99.2nMMore data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  502nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280343(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
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