BDBM280366 2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyridin-4-amine::US10030004, Compound 32::US10501436, Compound 32::US11053216, Compound 32::US11702401, Compound 32

SMILES Fc1ccc(Cl)cc1-c1cc(Nc2ccnc3[nH]ccc23)c(cn1)C1CC1

InChI Key InChIKey=NLTJLIGESBNQSN-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280366   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  2.54E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  3.33E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  2.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  6.10nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  2.54E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  5.84E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  3.33E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  2.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  6.10nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sid

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  2.54E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  5.84E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  3.33E+5nMMore data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  2.70nMMore data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  6.10nMMore data for this Ligand-Target Pair

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TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sid

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  2.54E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  5.84E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  3.33E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  2.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  6.10nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)Copy SMILESCopy InChI

Affinity DataIC50:  5.84E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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