BDBM280742 3-(2-{4-amino- 2-[6-chloro-1- (2-fluorobenzyl)- 1H-indazol-3- yl]-5-methyl-6- oxo-6,7- dihydro-5H- pyrrolo[2,3-d] pyrimidin-5-yl) oxazol-4-yl}-2,2- dimethyl- propanoic acid::US10030027, Example 3A::US10428076, Example 3A

SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)C(O)=O

InChI Key InChIKey=IUCOGXQLGDOPBO-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 280742   

TargetGuanylate cyclase soluble subunit alpha-1/beta-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM280742(3-(2-{4-amino- 2-[6-chloro-1- (2-fluorobenzyl)- 1H...)
Affinity DataKi:  0.0670nMAssay Description:The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM280742(3-(2-{4-amino- 2-[6-chloro-1- (2-fluorobenzyl)- 1H...)
Affinity DataKi:  0.0670nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent