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BDBM282134 N-(3,4-difluorobenzyl)-2- {[4-methyl-(3-(1-oxo- 2,3-dihydro-1H-isoindol- 5-yl)phenyl]amino} pyridine-3-carboxamide::US10030016, Example 17.2

SMILES: Cc1ccc(Nc2ncccc2C(=O)NCc2ccc(F)c(F)c2)cc1-c1ccc2C(=O)NCc2c1

InChI Key: InChIKey=STDXMBGYRWWXJV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 282134   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282134
PNG
(N-(3,4-difluorobenzyl)-2- {[4-methyl-(3-(1-oxo- 2,...)
Show SMILES Cc1ccc(Nc2ncccc2C(=O)NCc2ccc(F)c(F)c2)cc1-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C28H22F2N4O2/c1-16-4-7-20(13-23(16)18-6-8-21-19(12-18)15-33-27(21)35)34-26-22(3-2-10-31-26)28(36)32-14-17-5-9-24(29)25(30)11-17/h2-13H,14-15H2,1H3,(H,31,34)(H,32,36)(H,33,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair