BDBM283047 6-(1-(2,2-difluoroethyl)-4-(2-hydroxyphenyl)-1H- imidazol-5-yl)imidazo[1,2-b]pyridazine-3-carbonitrile::US10287295, Example 248'::US11352360, Example 248'::US9884868, Example 248'

SMILES Oc1ccccc1-c1ncn(CC(F)F)c1-c1ccc2ncc(C#N)n2n1

InChI Key InChIKey=BYNUJHIHRYVHIS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 283047   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283047(6-(1-(2,2-difluoroethyl)-4-(2-hydroxyphenyl)-1H- i...)
Affinity DataIC50:  0.700nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283047(6-(1-(2,2-difluoroethyl)-4-(2-hydroxyphenyl)-1H- i...)
Affinity DataIC50:  144nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283047(6-(1-(2,2-difluoroethyl)-4-(2-hydroxyphenyl)-1H- i...)
Affinity DataIC50:  144nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283047(6-(1-(2,2-difluoroethyl)-4-(2-hydroxyphenyl)-1H- i...)
Affinity DataIC50:  144nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283047(6-(1-(2,2-difluoroethyl)-4-(2-hydroxyphenyl)-1H- i...)
Affinity DataIC50:  0.700nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [T204D](Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283047(6-(1-(2,2-difluoroethyl)-4-(2-hydroxyphenyl)-1H- i...)
Affinity DataIC50:  0.700nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent