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BDBM284028 6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(pyrazine-2- carbonyl)piperazin-1- yl)pyridin-3- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile 2,2,2- trifluoroacetate::US10023570, Example 38::US10174027, Example 38

SMILES: Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2cnccn2)c2c(cnn2c1)C#N

InChI Key: InChIKey=CFTKEQPNNXBTRG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284028   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM284028
PNG
(6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(pyrazine-2-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2cnccn2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H22N10O/c1-33-16-21(14-31-33)19-10-22(25-20(11-27)13-32-36(25)17-19)18-2-3-24(30-12-18)34-6-8-35(9-7-34)26(37)23-15-28-4-5-29-23/h2-5,10,12-17H,6-9H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.5n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284028
PNG
(6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(pyrazine-2-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2cnccn2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H22N10O/c1-33-16-21(14-31-33)19-10-22(25-20(11-27)13-32-36(25)17-19)18-2-3-24(30-12-18)34-6-8-35(9-7-34)26(37)23-15-28-4-5-29-23/h2-5,10,12-17H,6-9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284028
PNG
(6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(pyrazine-2-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2cnccn2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H22N10O/c1-33-16-21(14-31-33)19-10-22(25-20(11-27)13-32-36(25)17-19)18-2-3-24(30-12-18)34-6-8-35(9-7-34)26(37)23-15-28-4-5-29-23/h2-5,10,12-17H,6-9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair