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BDBM284109 6-(1-methyl-1H-pyrazol-4-yl)- 4-(6-(4-(morpholine-4- carbonyl)piperazin-1- yl)pyridin-3-yl)pyrazolo[1,5- a]pyridine-3-carbonitrile::US10023570, Example 119::US10174027, Example 119

SMILES: Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)N2CCOCC2)c2c(cnn2c1)C#N

InChI Key: InChIKey=WSMUJCULCMZAED-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284109   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM284109
PNG
(6-(1-methyl-1H-pyrazol-4-yl)- 4-(6-(4-(morpholine-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)N2CCOCC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H27N9O2/c1-31-17-22(16-29-31)20-12-23(25-21(13-27)15-30-35(25)18-20)19-2-3-24(28-14-19)32-4-6-33(7-5-32)26(36)34-8-10-37-11-9-34/h2-3,12,14-18H,4-11H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29.1n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284109
PNG
(6-(1-methyl-1H-pyrazol-4-yl)- 4-(6-(4-(morpholine-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)N2CCOCC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H27N9O2/c1-31-17-22(16-29-31)20-12-23(25-21(13-27)15-30-35(25)18-20)19-2-3-24(28-14-19)32-4-6-33(7-5-32)26(36)34-8-10-37-11-9-34/h2-3,12,14-18H,4-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29.1n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284109
PNG
(6-(1-methyl-1H-pyrazol-4-yl)- 4-(6-(4-(morpholine-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)N2CCOCC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H27N9O2/c1-31-17-22(16-29-31)20-12-23(25-21(13-27)15-30-35(25)18-20)19-2-3-24(28-14-19)32-4-6-33(7-5-32)26(36)34-8-10-37-11-9-34/h2-3,12,14-18H,4-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29.1n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair