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BDBM284233 US10023570, Example 243::US10174027, Example 243

SMILES: Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NCC(F)(F)F)c2c(cnn2c1)C#N

InChI Key: InChIKey=SAJQZRNNGDPKSW-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284233   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa658-end)


(Homo sapiens (Human))
BDBM284233
PNG
(US10023570, Example 243 | US10174027, Example 243)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NCC(F)(F)F)c2c(cnn2c1)C#N
Show InChI InChI=1S/C25H23F3N8O/c1-34-13-20(12-32-34)18-8-21(23-19(9-29)11-33-36(23)14-18)17-2-3-22(30-10-17)35-6-4-16(5-7-35)24(37)31-15-25(26,27)28/h2-3,8,10-14,16H,4-7,15H2,1H3,(H,31,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.60n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284233
PNG
(US10023570, Example 243 | US10174027, Example 243)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NCC(F)(F)F)c2c(cnn2c1)C#N
Show InChI InChI=1S/C25H23F3N8O/c1-34-13-20(12-32-34)18-8-21(23-19(9-29)11-33-36(23)14-18)17-2-3-22(30-10-17)35-6-4-16(5-7-35)24(37)31-15-25(26,27)28/h2-3,8,10-14,16H,4-7,15H2,1H3,(H,31,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.60n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284233
PNG
(US10023570, Example 243 | US10174027, Example 243)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NCC(F)(F)F)c2c(cnn2c1)C#N
Show InChI InChI=1S/C25H23F3N8O/c1-34-13-20(12-32-34)18-8-21(23-19(9-29)11-33-36(23)14-18)17-2-3-22(30-10-17)35-6-4-16(5-7-35)24(37)31-15-25(26,27)28/h2-3,8,10-14,16H,4-7,15H2,1H3,(H,31,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.60n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair