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BDBM284255 US10023570, Example 265::US10174027, Example 265

SMILES: CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(c1)C(F)F

InChI Key: InChIKey=ZJTGMROGDILDST-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284255   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM284255
PNG
(US10023570, Example 265 | US10174027, Example 265)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(c1)C(F)F
Show InChI InChI=1S/C26H26F2N8O2/c1-26(2,3)38-25(37)34-8-6-33(7-9-34)22-5-4-17(12-30-22)21-10-18(20-14-32-36(16-20)24(27)28)15-35-23(21)19(11-29)13-31-35/h4-5,10,12-16,24H,6-9H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 153n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284255
PNG
(US10023570, Example 265 | US10174027, Example 265)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(c1)C(F)F
Show InChI InChI=1S/C26H26F2N8O2/c1-26(2,3)38-25(37)34-8-6-33(7-9-34)22-5-4-17(12-30-22)21-10-18(20-14-32-36(16-20)24(27)28)15-35-23(21)19(11-29)13-31-35/h4-5,10,12-16,24H,6-9H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 153n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284255
PNG
(US10023570, Example 265 | US10174027, Example 265)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(c1)C(F)F
Show InChI InChI=1S/C26H26F2N8O2/c1-26(2,3)38-25(37)34-8-6-33(7-9-34)22-5-4-17(12-30-22)21-10-18(20-14-32-36(16-20)24(27)28)15-35-23(21)19(11-29)13-31-35/h4-5,10,12-16,24H,6-9H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 153n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair