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BDBM284292 US10023570, Example 302::US10174027, Example 302

SMILES: Cn1cc(cn1)-c1cc(-c2ccc(cc2)C2CCN(CC2)C(=O)CC(C)(C)C)c2c(cnn2c1)C#N

InChI Key: InChIKey=YMWIVJYQFILSLI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284292   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa658-end)


(Homo sapiens (Human))
BDBM284292
PNG
(US10023570, Example 302 | US10174027, Example 302)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(cc2)C2CCN(CC2)C(=O)CC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H32N6O/c1-29(2,3)14-27(36)34-11-9-21(10-12-34)20-5-7-22(8-6-20)26-13-23(25-17-31-33(4)18-25)19-35-28(26)24(15-30)16-32-35/h5-8,13,16-19,21H,9-12,14H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 49.6n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284292
PNG
(US10023570, Example 302 | US10174027, Example 302)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(cc2)C2CCN(CC2)C(=O)CC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H32N6O/c1-29(2,3)14-27(36)34-11-9-21(10-12-34)20-5-7-22(8-6-20)26-13-23(25-17-31-33(4)18-25)19-35-28(26)24(15-30)16-32-35/h5-8,13,16-19,21H,9-12,14H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 49.6n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284292
PNG
(US10023570, Example 302 | US10174027, Example 302)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(cc2)C2CCN(CC2)C(=O)CC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H32N6O/c1-29(2,3)14-27(36)34-11-9-21(10-12-34)20-5-7-22(8-6-20)26-13-23(25-17-31-33(4)18-25)19-35-28(26)24(15-30)16-32-35/h5-8,13,16-19,21H,9-12,14H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 49.6n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair